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KMID : 0438319960050010063
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Pusan Journal of Psychiatry
1996 Volume.5 No. 1 p.63 ~ p.69
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A Study on Platelet-Poor Plasma 5-Hydroxytryptamine(5-HT) Levels in the Autistic Disorder
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김용관
김영훈/진성태/김선희/이덕내
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Abstract
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The author measured platelet-poor plasma 5-hydroxytryptamine(5-HT) levels in 23 autistic patients meeting the diagnostic criteria of DSM-III-R, their mothers, and 24 healthy control subjects, in order to elucidate the biochemical etiology, and
correlation between autistic patients and their mothers on 5-HT levels in the autistic disorder.
The results were summarized as follows.
1. In the autistic group, the mean platlet-poor plasma 5-HT levels were significantly lowered compared to the control group.
2. No significant correlation was found between the platelet-poor plasma 5-HT levels and the psychopathology, according to the diagnostic criteria of DSM-III-R in the autistic group.
3. No significant correlation was found between the autistic patients and their mothers on the platelet-poor plasma 5-HT levels.
These results support the hypothesis of a possible involvement of 5-HT dysfuntion in the biochemical etiology of the autistic disorder, but because the data of 5-HT levels in the platelet or whole blood were not obtained simulatneously, these
results
could not support the studies that increased 5-HT levels seen in autistic disorder are a result of increased uptake or facilitated storage of 5-HT by the platelet, and the author suggests that studies explicating the basic mechanism responsible
for
hyperserotonemia and the development of sophisticated instrument of assessment for psychopathology in the autistic disorder should be needed.
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KEYWORD
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